This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
EGFR Antibody (clone H9B4) LS-C357865
catalog :
LS-C357865
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H9B4

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunoprecipitation
product information
AntibodyID :
369410
AntibodyName :
LS-C357865
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
EGFR Antibody (clone H9B4) LS-C357865
Specificity :
Human EGFR
ClonalityDesc :
Monoclonal
CloneName :
H9B4
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
ImmunogenType :
Cells
ImmunogenDesc :
Purified EGFR from A431 cells.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 2°C to 8°C.
IsotypeName :
IgG1
Gene :
EGFR
StandardGeneSymbol :
EGFR
gene family :
Protein Kinase
Subfamily :
EGF Receptor
Reactivity :
Human
NonReactiveSpecies :
Mouse, Rat
Usage :
ELISA, IP, WB (0.5 - 1 µg/ml)
ShortWebDescription :
EGFR antibody LS-C357865 is an unconjugated mouse monoclonal antibody to human EGFR. Validated for ELISA, IP and WB.
UsageText :
Epidermal Growth Factor Receptor is a type I receptor tyrosine kinase, referred to as . EGFR , ErbB1 and HER1. When EGFR is activated by one of its ligands, it dimerizes. It can form a homodimer, heterodimers with other ErbB family members, or even a cluster of EGFRs. Activation stimulates EGFRs intracellular kinase activity. Autophosphorylation of tyrosine residues in the C-terminal domain of EGFR leads to association with proteins with phosphotyrosine-binding domains which then signal the initiation of signal transduction cascades including the JNK, MAPK, AKT, and possibly . Nf-KB , pathways. Overexpression of EGFR is the cause of some types of cancer, including lung and colon cancer. It has also been linked to psoriasis, eczema and atherosclerosis, although poorly defined. Monoclonal antibody to EGFR can be used to block the extracellular ligand binding domain, therebye blocking tyrosine kinase activation and subsequent signal transduction. ELISA: Order BSA-free antibody format for coating.
Synonyms :
EGFR, EGF Receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.