This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
KRT17 / CK17 / Cytokeratin 17 Antibody (clone E3) LS-C357843
catalog :
LS-C357843
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E3

The same clone is also sold as:
reactivity :
human, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
product information
AntibodyID :
369388
AntibodyName :
LS-C357843
TargetSpecies :
Rat
Host Species :
Mouse
Product Name :
KRT17 / CK17 / Cytokeratin 17 Antibody (clone E3) LS-C357843
Specificity :
KRT17 / CK17 / Cytokeratin 17
ClonalityDesc :
Monoclonal
CloneName :
E3
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
ImmunogenType :
Cell fraction
ImmunogenDesc :
The cytoskeletal fraction of rat colon epithelium.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 2°C to 8°C.
IsotypeName :
IgG2b,k
Gene :
KRT17 / CK17 / Cytokeratin 17
StandardGeneSymbol :
KRT17
gene family :
Keratin
Reactivity :
Goat, Bovine, Rat, Pig, Human
Usage :
ELISA, Flo (0.5 - 1 µg/10E6 cells), IF (1 - 2 µg/ml), IHC, IHC-P (0.5 - 1 µg/ml), IP, WB (0.5 - 1 µg/ml)
ShortWebDescription :
Cytokeratin 17 antibody LS-C357843 is an unconjugated mouse monoclonal antibody to Cytokeratin 17 (KRT17 / CK17) from rat. It is reactive with human, rat, bovine and other species. Validated for ELISA, Flow, IF, IHC, IP and WB.
UsageText :
Cytokeratin 17 (CK17, Keratin 17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IFP's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to cytokeratin 17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. It is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as [Character 93]epithelial stem cell[Character 94] marker because cytokeratin 17 antibody marks basal cell differentiation. Cytokeratin 17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. Cytokeratin 17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20% of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including cytokeratin 17 antibody. Also important is that cases of triple negative breast carcinoma with expression of keratin 17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually antibody to cytokeratin 17 and MUC1 immunoreactivity represents pancreatobiliary subtype whereas antibody to MUC2 and CDX2 positivity defines intestinal subtype. ELISA: Order BSA-free format for coating.
Synonyms :
KRT17, 39.1, Cytokeratin 17, Cytokeratin-17, K17, Keratin 17 epitope S2, Keratin 17 epitope S4, Keratin 17, PC2, PCHC1, CK-17, Keratin 17 epitope S1, Keratin-17
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.