This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CD46 Antibody (clone 122.2) LS-C357793
catalog :
LS-C357793
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
122.2

The same clone is also sold as:
reactivity :
human
application :
immunocytochemistry, flow cytometry
product information
AntibodyID :
369338
AntibodyName :
LS-C357793
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CD46 Antibody (clone 122.2) LS-C357793
Specificity :
Human CD46
ClonalityDesc :
Monoclonal
CloneName :
122.2
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human CD46 protein.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 2°C to 8°C.
IsotypeName :
IgG1,k
Gene :
CD46
StandardGeneSymbol :
CD46
Reactivity :
Human
Usage :
Flo (0.5 - 1 µg/10E6 cells), IF (0.5 - 1 µg/ml)
ShortWebDescription :
CD46 antibody LS-C357793 is an unconjugated mouse monoclonal antibody to human CD46. Validated for Flow and IF.
UsageText :
CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Synonyms :
CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.