This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CASP3 / Caspase 3 Antibody (clone CAS3836) LS-C357737
catalog :
LS-C357737
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CAS3836
reactivity :
human
application :
western blot
product information
AntibodyID :
369282
AntibodyName :
LS-C357737
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CASP3 / Caspase 3 Antibody (clone CAS3836) LS-C357737
Specificity :
Human CASP3 / Caspase 3
ClonalityDesc :
Monoclonal
CloneName :
CAS3836
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, pH 7.4, 0.1 mg/ml BSA, 0.05% Sodium Azide
ImmunogenDesc :
The large subunit domain of human Caspase-3.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG1,k
Gene :
CASP3 / Caspase 3
StandardGeneSymbol :
CASP3
gene family :
Protease
Subfamily :
Cysteine C14
Reactivity :
Mouse, Rat, Human
Usage :
WB (2 - 4 µg/ml)
ShortWebDescription :
Caspase 3 antibody LS-C357737 is an unconjugated mouse monoclonal antibody to Caspase 3 (CASP3) from human. It is reactive with human, mouse and rat. Validated for WB.
UsageText :
Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. They are often referred to as the 'executioners of apoptosis.' Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. Active caspase-1 and -3 are heterodimers, containing two small and two large subunits. Active Caspase-3 subunits are 17kD (p17) and 12kD (p12). Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. It is activated by Caspases -8, -9 and -10 ('initiator caspases') and then effects apoptosis by cleaving targeted cellular proteins. This antibody will detect the pro form and p17 and p12 active forms of Caspase-3.
Synonyms :
CASP3, Apopain, CASP-3, Caspase-3, CPP32B, CPP32, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Procaspase3, Caspase 3, CPP-32, PARP cleavage protease, Protein Yama
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.