This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-DES / Desmin Antibody (clone D33) LS-C347439
catalog :
LS-C347439
price :
275 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D33
reactivity :
human
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
358396
AntibodyName :
LS-C347439
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
Anti-DES / Desmin Antibody (clone D33) LS-C347439
Specificity :
The antibody D33 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e. g. rhabdomyosarcoma and leiomyosarcoma in human, hamster, rat and chicken. The antibody does not cross react with vimentin or any of the other intermediate filament proteins.
ClonalityDesc :
Monoclonal
CloneName :
D33
AntibodyModification :
Unconjugated
PresentationDesc :
Tissue culture supernatant
ImmunogenType :
Cells
ImmunogenDesc :
D33 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a BALB/c mouse immunized with purified desmin from a leiomyosarcoma.
PurificationDesc :
Tissue culture supernatant
RecommendedStorageDesc :
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG1
Gene :
DES / Desmin
StandardGeneSymbol :
DES
Reactivity :
Chicken, Rat, Hamster, Human
Usage :
ICC, IHC-Fr, IHC-P, WB
UsageText :
Desmin is a 53 kD intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i. e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Synonyms :
DES, ARVC7, ARVD7, CMD1I, CSM1, CSM2, MFM1, SCPNK, Desmin, Intermediate filament protein
ProductID :
382694
ProductNumber :
LS-C347439-1000
Volume :
1000 µl
LSListPrice :
275 USD
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.