product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
CD274 / B7-H1 / PD-L1 Antibody (clone OTI2C7) LS-C338364
catalog :
LS-C338364
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OTI2C7
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Reference
Hou J, Zhao R, Xia W, Chang C, You Y, Hsu J, et al. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020;22:1264-1275 pubmed publisher
Yang W, Cha J, Xia W, Lee H, Chan L, Wang Y, et al. Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018;78:3761-3768 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-C338364 image 1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD274 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD274.
image 2 :
LifeSpan Biosciences LS-C338364 image 2
Anti-CD274 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CD274.
product information
AntibodyID :
348975
AntibodyName :
LS-C338364
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CD274 / B7-H1 / PD-L1 Antibody (clone OTI2C7) LS-C338364
Specificity :
Human B7-H1 / PD-L1 / CD274
ClonalityDesc :
Monoclonal
CloneName :
OTI2C7
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol, 1% BSA
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Full length human recombinant protein of human CD274(NP_054862) produced in HEK293T cell.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG1
Gene :
CD274 / B7-H1 / PD-L1
StandardGeneSymbol :
CD274
Reactivity :
Human
NonReactiveSpecies :
Mouse
Usage :
IF (1:100), WB (1:200 - 1:2000)
ShortWebDescription :
PD-L1 antibody LS-C338364 is an unconjugated mouse monoclonal antibody to human PD-L1 (CD274 / B7-H1). Validated for IF and WB. Cited in 2 publications.
Synonyms :
CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.