This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CTNNB1 / Beta Catenin Antibody (phospho-Ser45) LS-C21256
catalog :
LS-C21256
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
21838
AntibodyName :
LS-C21256
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
CTNNB1 / Beta Catenin Antibody (phospho-Ser45) LS-C21256
Specificity :
Human -catenin. Mouse, rat and frog -catenin (100% homologous) have not been tested, but are expected to react.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
pSer45
PresentationDesc :
1 mg/ml BSA (IgG, Protease free), PBS (without Mg2+, Ca2+), pH 7.2, 0.1% Sodium Azide, 50% Glycerol
ImmunogenType :
Synthetic phospho-peptide
ImmunogenDesc :
Synthetic phosphopeptide derived from a region of human -catenin that contains serine 45. The sequence is conserved in mouse, rat and frog.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Gene :
CTNNB1 / Beta Catenin
StandardGeneSymbol :
CTNNB1
gene family :
Catenin
Reactivity :
Human
Usage :
ELISA, WB (1:1000 - 1:2000)
ShortWebDescription :
Beta Catenin antibody LS-C21256 is an unconjugated rabbit polyclonal antibody to human Beta Catenin (CTNNB1) (pSer45). Validated for ELISA and WB.
UsageText :
The antibody has been used for Western blotting applications. b-catenin (92kD) is a multifunctional protein involved in cell-cell adhesion, intracellular. signaling and gene transcription. b-catenin plays a key role in the Wnt pathway which mediates numerous developmental processes. Deregulation of the Wnt pathway results in the accumulation of b-catenin in the nucleus. Stabilizing mutations of several serine/threonine residues (more frequently of serine 45) have been found in multiple tumors. Phosphorylation of b-catenin on serine 45 by casein kinase I (CKI) primes its subsequent phosphorylation of residues 33, 37 and 41 by glycogen synthase-3b (GSK-3b) and results in its degradation. Applications: Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:2000.
Synonyms :
CTNNB1, Beta-catenin, Catenin beta-1, CTNNB, Beta Catenin
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.