antibody

CLU / Clusterin Antibody (clone Hs-3, Concentrated) LS-C204172

LS-C204172

monoclonal

mouse

nonconjugated

HS-3

The same clone is also sold as:

• Santa Cruz Biotechnology: sc-51579
• Invitrogen: MA1-19385
• Boster: M00590-1
• OriGene: AM03078PU-N, DM2012
• Abnova: MAB12529
• Exbio: 11-421-C100, 11-421-C025

western blot, ELISA, immunocytochemistry

LS-C204172

Human

Mouse

CLU / Clusterin Antibody (clone Hs-3, Concentrated) LS-C204172

Clusterin (SGP-2, SP-40,40, pADHC-9, TRPM-2, CLJ, T64, GP III, APO J, XIP8) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. It is a conserved secreted glycoprotein expressed by a wide range of tissues and being implicated in several physiological processes. Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiqitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has a number of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress-induced insults caused by degraded and misfolded protein precipitates. The protein is expressed in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. A genuin

Monoclonal

Hs-3

Concentrated Unconjugated

PBS, pH 7.4, 15 mM Sodium Azide

Protein fraction

Freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization

Purified

Store at 2-8°C.

IgG1

CLU / Clusterin

CLU

Human

ELISA, ICC, WB

Clusterin antibody LS-C204172 is an unconjugated mouse monoclonal antibody to human Clusterin (CLU). Validated for ELISA, ICC and WB.

CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40

Worldwide