This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03, Concentrated) LS-C204152
catalog :
LS-C204152
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SLP-76/03

The same clone is also sold as:
reactivity :
human
application :
western blot
product information
AntibodyID :
212408
AntibodyName :
LS-C204152
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03, Concentrated) LS-C204152
Specificity :
SLP-76 (SH2 domain-containing leukocyte protein) is an adaptor molecule that is involved in T cell development and activation. Thymocytes from transgenic mice expressing a SLP-76 mutant with deletion of the amino terminus are unable to develop to CD4-CD8- stage. Mature T cells do develop in mice expressing SLP-76 with mutations in proline rich region or SH2 domain, but they fail to upregulate CD69 or proliferate appropriately in response to anti-CD3 stimulation. SLP-76 is cytosolic protein identified as phosphoprotein migrating at 76 kD in SDS-PAGE. Amino-terminal domain of SLP-76 containing several tyrosines is followed by PR (proline rich) region and an SH2 domain. SLP-76 associates with LAT via Gads or Grb 2. The PR region of SLP-76 constitutively associates with carboxy-terminal SH3 domain of Gads and P-1 segment of the PR region was also identified that associates with the SH3 domain of PLC-gamma1. The PR region therefore provides another pathway for PLC-gamma1 recruitment to the LAT signalling complex in T cells. The SH2 domain of SLP-76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
ClonalityDesc :
Monoclonal
CloneName :
SLP-76/03
AntibodyModification :
Concentrated Unconjugated
AntigenModification :
aa216-434
PresentationDesc :
PBS, pH 7.4, 15 mM Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
A fusion protein representing amino acids 216-434 of human SLP-76
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 2-8°C.
IsotypeName :
IgG2b
Gene :
LCP2 / SLP-76
StandardGeneSymbol :
LCP2
Reactivity :
Human
Usage :
WB
ShortWebDescription :
SLP-76 antibody LS-C204152 is an unconjugated mouse monoclonal antibody to human SLP-76 (LCP2) (aa216-434). Validated for WB.
Synonyms :
LCP2, 76 kDa tyrosine phosphoprotein, Lymphocyte cytosolic protein 2, SLP-76, SLP-76 tyrosine phosphoprotein, SLP76
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.