This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CASP4 / Caspase 4 Antibody (N-Terminus, Concentrated) LS-C202788
catalog :
LS-C202788
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
product information
AntibodyID :
211044
AntibodyName :
LS-C202788
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
CASP4 / Caspase 4 Antibody (N-Terminus, Concentrated) LS-C202788
Specificity :
PS 298 recognizes an epitope within the N-terminal region (NT) of Caspase-4, otherwise known as ICH-2. Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localization of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimer's disease and Ischemia (1, 3) and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis. PS 298 detects a band of approximately 34 kD in Ramos cell lysates (predicted precursor MWT 31 kD).
ClonalityDesc :
Polyclonal
AntibodyModification :
Concentrated Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
PBS, 0.02% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
A 16 AA peptide from human Caspase-4 N-Terminus
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 2-8°C.
Gene :
CASP4 / Caspase 4
StandardGeneSymbol :
CASP4
gene family :
Protease
Subfamily :
Cysteine C14
Reactivity :
Human
Usage :
IHC, IHC-P, WB
ShortWebDescription :
Caspase 4 antibody LS-C202788 is an unconjugated rabbit polyclonal antibody to human Caspase 4 (CASP4) (N-Terminus). Validated for IHC and WB.
Synonyms :
CASP4, CASP-4, Casp11, Caspase 4, Caspase-4, Cysteine protease icerel-ii, ICE(rel)-II, ICE(rel)II, ICH-2, Ich-3, ICH2, Protease ICH-2, TX, Tx protease, Caspase 11, ICEREL-II, Mih1/TX, Protease TX
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.