This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TP53 / p53 Antibody (clone Pab122, Concentrated) LS-C202480
catalog :
LS-C202480
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Pab122

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
210736
AntibodyName :
LS-C202480
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TP53 / p53 Antibody (clone Pab122, Concentrated) LS-C202480
Specificity :
The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). P53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.
ClonalityDesc :
Monoclonal
CloneName :
Pab122
AntibodyModification :
Concentrated Unconjugated
PresentationDesc :
PBS, 0.05% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human p53 protein. Splenocytes were fused with mouse myeloma P3-X63/AG8.653 cells.
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 2-8°C.
IsotypeName :
IgG1,k
Gene :
TP53 / p53
StandardGeneSymbol :
TP53
gene family :
P53
Reactivity :
Human
Usage :
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
ShortWebDescription :
P53 antibody LS-C202480 is an unconjugated mouse monoclonal antibody to human p53 (TP53). Validated for ELISA, Flow, IHC and WB.
Synonyms :
TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.