product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
SIGLEC1 / CD169 / Sialoadhesin Antibody (clone MOMA-1, FITC) LS-C188785
catalog :
LS-C188785
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
MOMA-1
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 2017;127:321-334 pubmed publisher
product information
AntibodyID :
196688
AntibodyName :
LS-C188785
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
SIGLEC1 / CD169 / Sialoadhesin Antibody (clone MOMA-1, FITC) LS-C188785
Specificity :
Specific for CD169, also known as sialoadhesin. The antibody reacts with a subpopulation of mature resident tissue macrophages. No reactivity is seen with dendritic cells, peritoneal resident macrophages, peritoneal exudate cells or blood cells. Distinct macrophage subpopulations of lymphoid organs express the antigen. In the spleen, they are localized at the marginal sinus forming a ring around the periarteriolar lymphocyte sheath and follicular areas at the inner side of marginal zones. In lymph nodes, they are localized in the sinusoids and medullary cords but not within follicular areas or paracortex. In Peyer's patches they are localized in the interfollicular areas at the serosal side. Kupffer cells in the liver can be clearly stained by MOMA-1, although antigen expression is weaker than that seen in splenic macrophages. No MOMA-1 positive macrophages were found in the thymus. Reactivity was also negative in following organs tested so far (kidney, brain, skin). In non-lymphoid organs, the antigen is only found on a macrophage subpopulation in the lamina propria of the villi of the small intestine.
ClonalityDesc :
Monoclonal
CloneName :
MOMA-1
AntibodyModification :
FITC
PresentationDesc :
PBS, 0.09% Sodium Azide, 1% BSA
ImmunogenDesc :
Stromal (reticular) elements from spleen.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
SIGLEC1 / CD169 / Sialoadhesin
StandardGeneSymbol :
SIGLEC1
gene family :
Immunoglobulin
Reactivity :
Mouse
NonReactiveSpecies :
Rat, Human
Usage :
Flo (1:1), IF
ShortWebDescription :
Sialoadhesin antibody LS-C188785 is an FITC-conjugated rat monoclonal antibody to mouse Sialoadhesin (SIGLEC1 / CD169). Validated for Flow and IF. Cited in 1 publication.
UsageText :
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Synonyms :
SIGLEC1, CD169, CD169 antigen, SIGLEC-1, Sialoadhesin, SN, DJ1009E24.1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.