This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
JAG2 / Jagged-2 Antibody (clone HMJ2-1) LS-C188669
catalog :
LS-C188669
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
HMJ2-1

The same clone is also sold as:
reactivity :
human, mouse
application :
flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
196572
AntibodyName :
LS-C188669
TargetSpecies :
Mouse
Host Species :
Hamster
Product Name :
JAG2 / Jagged-2 Antibody (clone HMJ2-1) LS-C188669
Specificity :
Recognizes Jagged2, one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Jagged2 is expressed by stromal and thymic lymphoid cells, and by splenic macrophages and dendritic cells (DC), and plays a vital role during limb, craniofacial, tooth, and thymic development, as well as being implicated in the maintenance and function of neuronal cells in both the central (CNS) and enteric (gastrointestinal) nervous system. Studies have shown that the anti-tumor cytolytic activity of natural killer (NK) cells can be enhanced by Jagged2 stimulation, and that the vital role which DC Jagged2 expression plays in DC-mediated NK cell activation, may occur through the interaction between Jagged2 with Notch 2. Clone HMJ2-1 has been shown to cross-react with rat mast cell line RBL-2H3 in flow cytometry.
ClonalityDesc :
Monoclonal
CloneName :
HMJ2-1
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Cells
ImmunogenDesc :
Jagged2-expressing CHO cells.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
JAG2 / Jagged-2
StandardGeneSymbol :
JAG2
Reactivity :
Mouse
Usage :
Flo, IHC-Fr, IHC-P
ShortWebDescription :
Jagged-2 antibody LS-C188669 is an unconjugated hamster monoclonal antibody to mouse Jagged-2 (JAG2). Validated for Flow and IHC.
Synonyms :
JAG2, Jagged 2, SER2, HJ2, Jagged2, Protein jagged-2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.