This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CD276 / B7-H3 Antibody (aa1-242, clone MJ18) LS-C188635
catalog :
LS-C188635
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MJ18

The same clone is also sold as:
reactivity :
human, mouse
application :
flow cytometry
product information
AntibodyID :
196538
AntibodyName :
LS-C188635
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
CD276 / B7-H3 Antibody (aa1-242, clone MJ18) LS-C188635
Specificity :
Recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma. Studies have shown that clone MJ18 inhibits stimulated CD4+ T-cell proliferation.
ClonalityDesc :
Monoclonal
CloneName :
MJ18
AntibodyModification :
Unconjugated
AntigenModification :
aa1-242
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Fusion protein
ImmunogenDesc :
Mouse IgG2a Fc-CD276 (aa 1-242).
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
CD276 / B7-H3
StandardGeneSymbol :
CD276
Reactivity :
Mouse
Usage :
Flo (1:25 - 1:200)
ShortWebDescription :
B7-H3 antibody LS-C188635 is an unconjugated rat monoclonal antibody to mouse B7-H3 (CD276) (aa1-242). Validated for Flow.
Synonyms :
CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, B7H3, B7RP-2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.