This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
HIF1A / HIF1 Alpha Antibody (clone Halpha111a) LS-C188629
catalog :
LS-C188629
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Halpha111a

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry - paraffin section
product information
AntibodyID :
196532
AntibodyName :
LS-C188629
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
HIF1A / HIF1 Alpha Antibody (clone Halpha111a) LS-C188629
Specificity :
Recognizes human HIF1 alpha (HIF1A), otherwise known as Hypoxia-inducible factor 1-alpha, a widely expressed bHLH-PAS transcription factor, which acts as a critical regulatory protein in the host response to oxygen deprivation (hypoxia). HIF1A and HIF1B (HIF1 beta/ARNT) form the highly-conserved heterodimeric HIF-1 transcriptional complex. During hypoxic conditions, HIF1A accumulates in the nucleus and activates the transcription of many genes encoding proteins involved in the production of oxygen delivery and metabolic adaptation, such as vascular endothelial growth factor (VEGF) and glucose transporters. Under normal oxygen conditions, HIF1A is targeted by HIF prolyl-hydroxylase, followed by rapid protease degradation, which is inhibited during hypoxia. Overexpression of HIF1A occurs in many common human cancers, including pancreatic, bladder and renal carcinomas.
ClonalityDesc :
Monoclonal
CloneName :
Halpha111a
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human HIF1 alpha.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
HIF1A / HIF1 Alpha
StandardGeneSymbol :
HIF1A
Reactivity :
Human
Usage :
IHC-P (1:25)
ShortWebDescription :
HIF1 Alpha antibody LS-C188629 is an unconjugated mouse monoclonal antibody to human HIF1 Alpha (HIF1A). Validated for IHC.
Synonyms :
HIF1A, ARNT-interacting protein, ARNT interacting protein, BHLHe78, HIF1 Alpha, Hypoxia-inducible factor1alpha, HIF-1A, HIF1, MOP1, Member of PAS superfamily 1, PASD8, HIF-1-alpha, HIF-1alpha, HIF1-ALPHA, Member of PAS protein 1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.