This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
APOE / Apolipoprotein E Antibody (clone WUE-4) LS-C188624
catalog :
LS-C188624
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
WUE-4

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
196527
AntibodyName :
LS-C188624
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
APOE / Apolipoprotein E Antibody (clone WUE-4) LS-C188624
Specificity :
Recognizes an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents. Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB, E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype. Clone WUE-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E cell receptor.
ClonalityDesc :
Monoclonal
CloneName :
WUE-4
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Purified protein
ImmunogenDesc :
Purified ApoHDL fraction.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
APOE / Apolipoprotein E
StandardGeneSymbol :
APOE
Reactivity :
Human
Usage :
ELISA (1:100 - 1:1000), WB
ShortWebDescription :
Apolipoprotein E antibody LS-C188624 is an unconjugated mouse monoclonal antibody to human Apolipoprotein E (APOE). Validated for ELISA and WB.
Synonyms :
APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.