This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
P2RX7 / P2X7 Antibody (clone Hano43) LS-C188553
catalog :
LS-C188553
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
Hano43

The same clone is also sold as:
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
product information
AntibodyID :
196456
AntibodyName :
LS-C188553
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
P2RX7 / P2X7 Antibody (clone Hano43) LS-C188553
Specificity :
Recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
ClonalityDesc :
Monoclonal
CloneName :
Hano43
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Cells
ImmunogenDesc :
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2b
Gene :
P2RX7 / P2X7
StandardGeneSymbol :
P2RX7
gene family :
Ion Channel
Subfamily :
P2X receptor
Reactivity :
Mouse
Usage :
Flo (1:25 - 1:200), IF
ShortWebDescription :
P2X7 antibody LS-C188553 is an unconjugated rat monoclonal antibody to mouse P2X7 (P2RX7). Validated for Flow and IF.
Synonyms :
P2RX7, ATP receptor, p2X purinoceptor 7, p2X receptor 7, p2X7 purinoceptor, p2Z receptor, Purinergic receptor, p2RX7, p2X7, p2X7 receptor
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.