This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
F8 / FVIII / Factor VIII Antibody (clone RFF-VIIIC/10) LS-C188520
catalog :
LS-C188520
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
RFF-VIIIC/10

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, radioimmunoassay
product information
AntibodyID :
196423
AntibodyName :
LS-C188520
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
F8 / FVIII / Factor VIII Antibody (clone RFF-VIIIC/10) LS-C188520
Specificity :
Recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Clone RFF-VIIIC/10 recognizes an epitope within the non-functional, middle domain of full-length Factor VIII.
ClonalityDesc :
Monoclonal
CloneName :
RFF-VIIIC/10
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Purified protein
ImmunogenDesc :
Affinity purified human Factor VIII.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
F8 / FVIII / Factor VIII
StandardGeneSymbol :
F8
Reactivity :
Human
NonReactiveSpecies :
Mouse, Dog, Rat
Usage :
ELISA, RIA, WB (1:100)
ShortWebDescription :
Factor VIII antibody LS-C188520 is an unconjugated mouse monoclonal antibody to human Factor VIII (F8 / FVIII). Validated for ELISA, RIA and WB.
Synonyms :
F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.