This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
ESR2 / ER Beta Antibody (aa493-504, clone 5/25) LS-C188515
catalog :
LS-C188515
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5/25

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
196418
AntibodyName :
LS-C188515
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
ESR2 / ER Beta Antibody (aa493-504, clone 5/25) LS-C188515
Specificity :
Recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). Although only the ERB1 variant appears fully functional, the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription. Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, and to be present in all primary colorectal carcinomas studied. Studies also revealed the nuclear expression of ERB5 in the majority of breast carcinomas tested, with a possible association with improved patient survival.
ClonalityDesc :
Monoclonal
CloneName :
5/25
AntibodyModification :
Unconjugated
AntigenModification :
aa493-504
PresentationDesc :
PBS, 0.1% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Tuberculin conjugated synthetic peptide LLSHVRHARYAP derived from the C-Terminus of human ERB5. Percent identity by BLAST analysis: Human (100%); Ferret (92%).
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
ESR2 / ER Beta
StandardGeneSymbol :
ESR2
gene family :
NHR
Subfamily :
NR3 Steroid receptor
Reactivity :
Human
Usage :
IHC-P, WB
ShortWebDescription :
ER Beta antibody LS-C188515 is an unconjugated mouse monoclonal antibody to human ER Beta (ESR2) (aa493-504). Validated for IHC and WB.
Synonyms :
ESR2, ESTRB, ER Beta, ERbeta, ER-BETA, ESR-BETA, ESRB, Estrogen receptor 2 (ER beta), NR3A2, Estrogen receptor beta, Estrogen receptor beta 4
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.