This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CTLA4 / CD152 Antibody (clone 1B8, Low Endotoxin) LS-C188473
catalog :
LS-C188473
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
1B8

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry
product information
AntibodyID :
196376
AntibodyName :
LS-C188473
TargetSpecies :
Mouse
Host Species :
Hamster
Product Name :
CTLA4 / CD152 Antibody (clone 1B8, Low Endotoxin) LS-C188473
Specificity :
Recognizes mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naive T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis. Clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumor immunity.
ClonalityDesc :
Monoclonal
CloneName :
1B8
AntibodyModification :
Low Endotoxin Unconjugated
PresentationDesc :
PBS
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Extracellular portion of mouse CD152 fused to a mouse IgG2a.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
CTLA4 / CD152
StandardGeneSymbol :
CTLA4
Reactivity :
Mouse
Usage :
ELISA, Flo (1:10 - 1:100), IF, IP, WB
ShortWebDescription :
CD152 antibody LS-C188473 is an unconjugated hamster monoclonal antibody to mouse CD152 (CTLA4). Validated for ELISA, Flow, IF, IP and WB.
UsageText :
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Synonyms :
CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.