This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
SOS1 Antibody (clone SOS-01) LS-C188432
catalog :
LS-C188432
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SOS-01

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunocytochemistry
product information
AntibodyID :
196335
AntibodyName :
LS-C188432
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
SOS1 Antibody (clone SOS-01) LS-C188432
Specificity :
Recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.
ClonalityDesc :
Monoclonal
CloneName :
SOS-01
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Elephant, Panda, Bovine, Cat, Horse, Rabbit, Opossum, Guinea pig (100%); Dog, Turkey, Zebra finch (95%); Lizard (89%).
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
SOS1
StandardGeneSymbol :
SOS1
Reactivity :
Human
Usage :
ELISA, IF, WB (1 µg/ml)
ShortWebDescription :
SOS1 antibody LS-C188432 is an unconjugated mouse monoclonal antibody to human SOS1. Validated for ELISA, IF and WB.
Synonyms :
SOS1, GINGF, NS4, SOS-1, Son of sevenless homolog 1, GF1, GGF1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.