This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
NQO1 Antibody (clone A180) LS-C188428
catalog :
LS-C188428
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A180

The same clone is also sold as:
reactivity :
human
application :
western blot, immunoprecipitation, immunohistochemistry - paraffin section
product information
AntibodyID :
196331
AntibodyName :
LS-C188428
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
NQO1 Antibody (clone A180) LS-C188428
Specificity :
Recognizes human NQO1 (NAD(P)H: quinone oxidoreductase 1), a 31kD cytosolic flavoenzyme and member of the NAD(P)H dehydrogenase (quinone) family, involved in detoxification, which catalyzes the two-electron reduction of quinones to hydroquinones. NQO1 is expressed in a wide range of tissues and is overexpressed in many human tumors including lung, brain, liver, colon and breast. The ability of NQO1 to bioactivate anti-tumor quinones including mitomycin C and diaziquone, has become a focus area for chemotherapeutic studies. Mutations in the NQO1 gene are associated with an increased risk of certain cancers, and an increased risk of leukaemia has been associated with diminished NQO1 activity and the NQO1 *2 allele. Clone A180 detects endogenous levels of total NQO1, and does not cross-react with NQO2. Clone A180 is reported as suitable for use in immunofluorescence studies.
ClonalityDesc :
Monoclonal
CloneName :
A180
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenDesc :
Purified recombinant human NQO1.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
NQO1
StandardGeneSymbol :
NQO1
Reactivity :
Human
NonReactiveSpecies :
Mouse
Usage :
IHC-P, IP, WB (1:100 - 1:1000)
ShortWebDescription :
NQO1 antibody LS-C188428 is an unconjugated mouse monoclonal antibody to human NQO1. Validated for IHC, IP and WB.
Synonyms :
NQO1, Azoreductase, DHQU, DT-diaphorase, Dioxin-inducible 1, DIA4, Diaphorase-4, NAD(P)H:quinone oxireductase, Phylloquinone reductase, QR1, Menadione reductase, NMOR1, NMORI, DTD, Quinone reductase 1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.