This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
ITGA4 / VLA-4 / CD49d Antibody (clone MRalpha4-1, Low Endotoxin) LS-C188415
catalog :
LS-C188415
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MRalpha4-1
reactivity :
human, rat
application :
immunoprecipitation, flow cytometry
product information
AntibodyID :
196318
AntibodyName :
LS-C188415
TargetSpecies :
Rat
Host Species :
Mouse
Product Name :
ITGA4 / VLA-4 / CD49d Antibody (clone MRalpha4-1, Low Endotoxin) LS-C188415
Specificity :
Recognizes rat CD49d, otherwise known as integrin alpha 4 chain/VLA-4, a 150kD type-1 transmembrane glycoprotein and member of the integrin alpha chain family, which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes, monocytes, thymocytes, mast cells and dendritic cells and is involved in cell-cell interactions, mononuclear cell trafficking to sites of endothelial inflammation, and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitro and in vivo functions of CD49d. Studies have shown that in rat Peyers patches, clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV), and significantly inhibits the transendothelial migration of T lymphocytes.
ClonalityDesc :
Monoclonal
CloneName :
MRalpha4-1
AntibodyModification :
Low Endotoxin Unconjugated
PresentationDesc :
PBS
ImmunogenType :
Cells
ImmunogenDesc :
RBL-2H3 rat basophilic leukaemia cell line.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
ITGA4 / VLA-4 / CD49d
StandardGeneSymbol :
ITGA4
gene family :
Integrin
Reactivity :
Rat
Usage :
Flo (1:10 - 1:100), IP
ShortWebDescription :
CD49d antibody LS-C188415 is an unconjugated mouse monoclonal antibody to rat CD49d (ITGA4 / VLA-4). Validated for Flow and IP.
UsageText :
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Synonyms :
ITGA4, 269C wild type, CD49D, IA4, Integrin alpha-4, Integrin alpha 4, Integrin alpha-4 subunit, Integrin alpha-IV, VLA-4, VLA-4 subunit alpha, CD49d antigen
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.