This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
MALT1 Antibody (aa701-808, clone 50) LS-C188408
catalog :
LS-C188408
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
50

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
196311
AntibodyName :
LS-C188408
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
MALT1 Antibody (aa701-808, clone 50) LS-C188408
Specificity :
Recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), a 93kD paracaspase which has been reported to demonstrate proteolytic activity. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB. MALT1 was initially identified as a recurrent translocation t(11;18)(q21: q21) in mucosal-associated lymphomas, which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2. Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent. The antibody is reported to recognize both MALT1 and the MALT1-API2 fusion protein.
ClonalityDesc :
Monoclonal
CloneName :
50
AntibodyModification :
Unconjugated
AntigenModification :
aa701-808
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenDesc :
Recombinant protein corresponding to aa701-808 located within the C-Terminus of MALT1.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
MALT1
StandardGeneSymbol :
MALT1
gene family :
Protease
Subfamily :
Cysteine C14
Reactivity :
Human
Usage :
IHC-P (1:25 - 1:100), WB
ShortWebDescription :
MALT1 antibody LS-C188408 is an unconjugated mouse monoclonal antibody to human MALT1 (aa701-808). Validated for IHC and WB.
Synonyms :
MALT1, Caspase-like protein, MLT, MLT1, Paracaspase, MALT associated translocation
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.