This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
LMO2 Antibody (clone 1A9-1) LS-C188391
catalog :
LS-C188391
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1A9-1
reactivity :
human
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
product information
AntibodyID :
196294
AntibodyName :
LS-C188391
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
LMO2 Antibody (clone 1A9-1) LS-C188391
Specificity :
Recognizes the human LIM-only protein (LMO2), a 24kD transcription factor that interacts with DNA binding proteins such as TAL1/SCL and GATA1. In early development, LMO2 is expressed in the central nervous system and a wide range of tissue, and in adults in myeloid and erythroid precursors, in normal germinal centre B-cells, endothelial cells and parts of the brain. LMO2 plays a vital role in early stages of haematopoiesis and in regulating yolk-sac erythropoiesis in mice. Studies suggest that it may also play a role in angiogenesis. A major cause of T-cell acute lymphoblastic leukemia (T-ALL) is the aberrant activation of the TAL1/SCL, LMO1/2, and NOTCH1 oncogenes. Activation of the Notch signalling pathway by mutations in either the gamma-secretase or PEST domains are found in more than 50% of all T-ALL, including LMO2-induced T-ALL, and studies using mouse models, have show that activation of Notch co-operates with Scl/Lmo1 in inducing T-ALL. Aberrant expression of LMO2 has also been linked to certain types of B-cell lymphoma, and LMO2 is reported to be expressed in prostate cancer, with overexpression possibly linked to cancer progression.
ClonalityDesc :
Monoclonal
CloneName :
1A9-1
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Fusion protein
ImmunogenDesc :
Purified GST-LMO2 fusion protein.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
LMO2
StandardGeneSymbol :
LMO2
Reactivity :
Human
Usage :
IF, IHC-P, WB
ShortWebDescription :
LMO2 antibody LS-C188391 is an unconjugated mouse monoclonal antibody to human LMO2. Validated for IF, IHC and WB.
Synonyms :
LMO2, LIM domain only protein 2, LMO-2, RHOM2, RBTNL1, Rhombotin 2, Rhombotin-like 1, Cysteine-rich protein TTG-2, RBTN2, Rhombotin-2, T-cell translocation gene 2, T-cell translocation protein 2, TTG2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.