This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
MMP9 / Gelatinase B Antibody (N-Terminus, clone 4A3) LS-C188390
catalog :
LS-C188390
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4A3

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
196293
AntibodyName :
LS-C188390
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
MMP9 / Gelatinase B Antibody (N-Terminus, clone 4A3) LS-C188390
Specificity :
Recognizes the active form of human matrix metalloproteinase 9 (MMP-9). The MMPs are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMPs are synthesized as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-9 is a gelatinase, cleaving type IV collagen and gelatin. The gelatinases have an additional gelatin-binding domain inserted in the catalytic domain. MMP-9, alongside other MMPs, plays a role in normal tissue remodeling such as embryonic development, ovulation, mammary gland involution and wound healing. It is important in the early stages of tumor invasion as it degrades the type IV collagen in the basement membrane. The antibody recognizes only the active form of MMP-9. It does not react with the MMP-9 proenzyme or the active or proenzyme forms of MMP-2.
ClonalityDesc :
Monoclonal
CloneName :
4A3
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Ovalbumin conjugated synthetic peptide corresponding to a region within the N-Terminus of human MMP-9.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
MMP9 / Gelatinase B
StandardGeneSymbol :
MMP9
gene family :
Protease
Subfamily :
Metallopeptidase M10A
Reactivity :
Human
Usage :
IHC-P (1:25 - 1:100), WB
ShortWebDescription :
Gelatinase B antibody LS-C188390 is an unconjugated mouse monoclonal antibody to human Gelatinase B (MMP9) (N-Terminus). Validated for IHC and WB.
Synonyms :
MMP9, 92kd gelatinase, 92 kDa gelatinase, Matrix metalloproteinase-9, MMP-9, CLG4B, Gelatinase B, GELB, Macrophage gelatinase, MANDP2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.