This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
MMP1 Antibody (C-Terminus, clone 3B6) LS-C188387
catalog :
LS-C188387
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3B6

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
196290
AntibodyName :
LS-C188387
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
MMP1 Antibody (C-Terminus, clone 3B6) LS-C188387
Specificity :
Recognizes human matrix metalloproteinase 1 (MMP-1). The MMPs are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMPs are synthesized as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. It is overexpressed in invasive melanoma, colorectal and esophageal cancers. It has also been implicated in arthritis and might influence atherosclerotic lesion formation. It might also be involved in the repair processes of the heart after myocardial infarction.
ClonalityDesc :
Monoclonal
CloneName :
3B6
AntibodyModification :
Unconjugated
AntigenModification :
C-Terminus
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Ovalbumin conjugated synthetic peptide corresponding to a region within the C-Terminus of human MMP-1.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
MMP1
StandardGeneSymbol :
MMP1
gene family :
Protease
Subfamily :
Metallopeptidase M10A
Reactivity :
Human
Usage :
IHC-P, WB
ShortWebDescription :
MMP1 antibody LS-C188387 is an unconjugated mouse monoclonal antibody to human MMP1 (C-Terminus). Validated for IHC and WB.
Synonyms :
MMP1, CLG, Matrix metalloprotease 1, MMP-1, Interstitial collagenase, Matrix metalloproteinase 1, Matrix metalloproteinase-1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.