This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
EPOR / EPO Receptor Antibody (Extracellular Domain) LS-C187856
catalog :
LS-C187856
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunoprecipitation
product information
AntibodyID :
195759
AntibodyName :
LS-C187856
TargetSpecies :
Human
Host Species :
Sheep
Product Name :
EPOR / EPO Receptor Antibody (Extracellular Domain) LS-C187856
Specificity :
Recognizes Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function. AHP1825 has been shown to block Iodine125 labeled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies, see for details. AHP1825 is reported as suitable for use in immunocytochemistry. AHP1825 has been reported for use in functional studies. Removal of Sodium Azide is recommended prior to use in functional assays. The recommended concentration for functional assays is 500 ug/ml.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
Extracellular Domain
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Fusion protein
ImmunogenDesc :
Partial cDNA of the extracellular domain of human EpoR expressed as a GST fusion protein in E. coli.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
EPOR / EPO Receptor
StandardGeneSymbol :
EPOR
gene family :
Cytokine Receptor
Reactivity :
Human
Usage :
ELISA, IP (10 µg/ml), WB (10 µg/ml)
ShortWebDescription :
EPO Receptor antibody LS-C187856 is an unconjugated sheep polyclonal antibody to human EPO Receptor (EPOR) (Extracellular Domain). Validated for ELISA, IP and WB.
Synonyms :
EPOR, EPO Receptor, EPO-R, Erythropoietin receptor
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.