This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
IL23R Antibody (aa59-87) LS-C187852
catalog :
LS-C187852
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
product information
AntibodyID :
195755
AntibodyName :
LS-C187852
TargetSpecies :
Human
Host Species :
Goat
Product Name :
IL23R Antibody (aa59-87) LS-C187852
Specificity :
Recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kD single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two domains. Multiple potential isoforms formed by alternative splicing are described. Recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4, the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis. Is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa59-87
PresentationDesc :
PBS, 0.1% Sodium Azide, 0.1% BSA
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-Terminus of human IL-23 receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%); Marmoset, Dog (97%); Gibbon, Monkey, Panda (93%); Ferret, Bovine, Cat, Horse, Pig (90%).
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
IL23R
StandardGeneSymbol :
IL23R
gene family :
Interleukin
Reactivity :
Human
Usage :
IHC, IHC-P (1:125), WB (1:500)
ShortWebDescription :
IL23R antibody LS-C187852 is an unconjugated goat polyclonal antibody to human IL23R (aa59-87). Validated for IHC and WB.
UsageText :
Use in IHC requires heat treatment prior to staining.
Synonyms :
IL23R, IL-23 receptor, Interleukin 23 receptor, IBD17, IL-23R, Interleukin-23 receptor
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.