This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CCR6 Antibody (aa18-46) LS-C187844
catalog :
LS-C187844
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section
product information
AntibodyID :
195747
AntibodyName :
LS-C187844
TargetSpecies :
Human
Host Species :
Goat
Product Name :
CCR6 Antibody (aa18-46) LS-C187844
Specificity :
Recognizes human CD196, otherwise known as CCR6 (C-C chemokine receptor type 6), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a specific receptor for the C-C chemokine LARC (Liver and activation-regulated chemokine)/MIP-3alpha, a selective chemoattractant which induces calcium flux in CD196-expressing lymphocytes. CD196 is preferentially expressed by B cells, memory T cells and immature dendritic cells and plays an important role in B lineage maturation and antigen-driven B cell differentiation. CD196 acts as a co-receptor for HIV1 infection, and is selectively expressed by mucosa-associated non-Hodgkin's lymphoma, making the interaction between CD196 and LARC a potential therapeutic target in these malignancies. Cross-reacts with mouse CD196, where linear epitopes are accessible.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa18-46
PresentationDesc :
PBS, 0.1% Sodium Azide, 0.1% BSA
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide YFVSVNTSYYSVDSEMLLCSLQEVRQFSR corresponding to amino acids 18-46 of human CD196. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Chimpanzee (97%); Monkey (86%).
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
CCR6
StandardGeneSymbol :
CCR6
gene family :
GPCR
Subfamily :
Chemokine
Reactivity :
Human
Usage :
ELISA (1:35000), IHC, IHC-P (5 µg/ml), WB (1:250)
ShortWebDescription :
CCR6 antibody LS-C187844 is an unconjugated goat polyclonal antibody to human CCR6 (aa18-46). Validated for ELISA, IHC and WB.
Synonyms :
CCR6, C-c chemokine receptor 6, CD196 antigen, BN-1, C-C chemokine receptor type 6, C-C CKR-6, Chemokine c-c motif receptor 6, CKRL3, CMKBR6, Chemokine (C-C) receptor 6, Chemokine receptor-like 3, Cc chemokine receptor 6, CC-CKR-6, CCR-6, DCR2, DRY6, G protein-coupled receptor 29, DRY-6, G-protein coupled receptor 29, GPR29, GPRCY4, Strl-22, STRL22, CD196, CKR-L3, GPR-CY4, LARC receptor
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.