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product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
EDNRB / Endothelin B Receptor Antibody (aa424-437) LS-C187726
catalog :
LS-C187726
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
human, rat
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
product information
AntibodyID :
195629
AntibodyName :
LS-C187726
TargetSpecies :
Rat
Host Species :
Sheep
Product Name :
EDNRB / Endothelin B Receptor Antibody (aa424-437) LS-C187726
Specificity :
Recognizes an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. AAR43 recognizes epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. AAR43 does not block the binding of endothelins. AAR43 is reported as suitable for use in immunocytochemistry on acetone fixed cells.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa424-437
PresentationDesc :
PBS, less than 0.1% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Keyhole limpet hemocyanin (KLH) conjugated C-Terminus peptide KANDHGYDNFRSSNN corresponding to amino acids 424 to 437 of rat endothelin B receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Sheep, Goat, Hamster, Elephant, Panda, Cat, Bovine, Dog, Horse, Rabbit, Pig, Opossum, Zebra finch, Chicken, Platypus (93%); Lizard (87%).
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
EDNRB / Endothelin B Receptor
StandardGeneSymbol :
EDNRB
gene family :
GPCR
Subfamily :
Endothelin
Reactivity :
Rat
Usage :
IF (10 - 20 µg/ml), IHC, IHC-P (10 - 20 µg/ml), IP (20 - 40 µg/ml)
ShortWebDescription :
Endothelin B Receptor antibody LS-C187726 is an unconjugated sheep polyclonal antibody to rat Endothelin B Receptor (EDNRB) (aa424-437). Validated for IF, IHC and IP.
Synonyms :
EDNRB, ABCDS, Endothelin B receptor, Etb receptor, ET-B, Et-b receptor, Et-b-r, ET-RB, ETBR, ETRB, Etb-svr, WS4A, Endothelin receptor type B, ET-BR, ETB, HSCR, HSCR2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.
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