This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Insulin Antibody LS-C187656
catalog :
LS-C187656
clonality :
polyclonal
host :
guinea-pigs
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
195559
AntibodyName :
LS-C187656
TargetSpecies :
Pig
Host Species :
Guinea pig
Product Name :
Insulin Antibody LS-C187656
Specificity :
Guinearecognizes porcine insulin, a hormone secreted by the beta cells of the islets of Langerhans in the pancreas. Insulin belongs to a family of hormones including the insulin-like growth hormones and the relaxins. The insulin precursor is a 108amino acid polypeptide consisting of a 24 aa signal peptide, an insulin A chain, a prohormone polypeptide and an insulin B chain together having a predicted molecular mass of 11672 Da. Active insulin migrates with an apparent molecular mass of 6kD in western blotting of porcine, bovine and lapine samples. Insulin is a hormone that functions in carbohydrate homeostasis, and acts to decrease blood glucose concentration by increasing cell permeability to monosaccharides, amino acids and fatty acids, and accelerate glycolysis and glycogen synthesis in the liver, it induces uptake of glucose into cells through its interaction with the glucose transporter GLUT4. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B-cell origin such as insulinoma. Guineahas been successfully used to demonstrate the presence of insulin in the islets of Langerhans of murine pancreas using immunohistochemistry on paraffin embedded material.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Native protein
ImmunogenDesc :
Native
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
Insulin
StandardGeneSymbol :
INS
gene family :
Hormone
Reactivity :
Pig
Usage :
ELISA, IHC-Fr (1:50 - 1:1600), IHC-P
ShortWebDescription :
Insulin antibody LS-C187656 is an unconjugated guinea pig polyclonal antibody to pig Insulin. Validated for ELISA and IHC.
Synonyms :
INS, IRDN, IDDM2, Preproinsulin, ILPR, Insulin, MODY10, Proinsulin
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.