This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TIMD4 / TIM4 / TIM-4 Antibody (clone RMT4-54) LS-C187579
catalog :
LS-C187579
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
RMT4-54

The same clone is also sold as:
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
product information
AntibodyID :
195482
AntibodyName :
LS-C187579
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
TIMD4 / TIM4 / TIM-4 Antibody (clone RMT4-54) LS-C187579
Specificity :
Clone RMT4-54 specifically recognizes mouse Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) see for details.
ClonalityDesc :
Monoclonal
CloneName :
RMT4-54
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenDesc :
Tim-4-Ig, consisting of amino acids 1-288 of mouse Tim-4, coupled with the Fc portion of mouse IgG2a.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
TIMD4 / TIM4 / TIM-4
StandardGeneSymbol :
TIMD4
Reactivity :
Mouse
Usage :
Flo, IF, IHC, IHC-P
ShortWebDescription :
TIM-4 antibody LS-C187579 is an unconjugated rat monoclonal antibody to mouse TIM-4 (TIMD4 / TIM4). Validated for Flow, IF and IHC.
Synonyms :
TIMD4, SMUCKLER, TIM-4, T-cell membrane protein 4, TIM4, TIMD-4, TIM 4
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.