This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
SIGLEC10 Antibody (clone 5G6) LS-C187565
catalog :
LS-C187565
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5G6

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
product information
AntibodyID :
195468
AntibodyName :
LS-C187565
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
SIGLEC10 Antibody (clone 5G6) LS-C187565
Specificity :
Clone 5G6 specifically recognizes human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see for details.
ClonalityDesc :
Monoclonal
CloneName :
5G6
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human Siglec-10, fused with the Fc region of human IgG.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
SIGLEC10
StandardGeneSymbol :
SIGLEC10
Reactivity :
Human
Usage :
Flo
ShortWebDescription :
SIGLEC10 antibody LS-C187565 is an unconjugated mouse monoclonal antibody to human SIGLEC10. Validated for Flow.
Synonyms :
SIGLEC10, SIGLEC-10, Siglec-like gene 2, Siglec-like protein 2, PRO940, SLG2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.