This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CDH2 / N Cadherin Antibody (Cytoplasmic Domain, clone 13A9) LS-C187536
catalog :
LS-C187536
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
13A9

The same clone is also sold as:
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
195439
AntibodyName :
LS-C187536
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CDH2 / N Cadherin Antibody (Cytoplasmic Domain, clone 13A9) LS-C187536
Specificity :
Recognizes neural cadherin, otherwise known as CD325, a calcium dependent cell-cell adhesion glycoprotein, and member of the cadherin superfamily, which links to the actin cytoskeleton via catenins, and plays a role in cell-matrix adhesion, cell growth and differentiation, and the establishment of left-right asymmetry. N-cadherin is expressed by neurons, endothelial cells, muscle cells, and stem cells, and is one of the primary cadherins recruited to the site of neuronal synapse formation. N-cadherin is directly involved in the differentiation of early hematopoietic progenitors, and is commonly expressed by cancer cells, playing a role in transendothelial migration and metastasis, through the up-regulation of the src kinase pathway, and subsequent failure of the intercellular connection between two adjacent endothelial cells. Studies using clone 13A9 have demonstrated that expression levels of E-Cadherin and N-Cadherin have a role to play in the invasive properties of breast cancer. Decreased levels of E-cadherin and loss of E-cadherin-mediated adhesion, can result in the transition of a benign epithelial tumor to an invasive tumor, and increase invasiveness, whilst the expression of N-cadherin correlates with motility, invasiveness and tumor metastasis, irrespective of the presence of E-cadherin see for details. Clone 13A9 has been shown to be specific for N-cadherin, and does not recognize E-cadherin, M-cadherin or P-cadherin, see for details. Immunohistological studies have shown that clone 13A9 can be used as a reliable marker for the differential diagnosis of pleural mesotheliomas and lung adenocarcinomas, when used in conjunction with E-cadherin see for details.
ClonalityDesc :
Monoclonal
CloneName :
13A9
AntibodyModification :
Unconjugated
AntigenModification :
Cytoplasmic Domain
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Fusion protein
ImmunogenDesc :
Recombinant MBP fusion protein containing the entire cytoplasmic domain of human N-cadherin.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
CDH2 / N Cadherin
StandardGeneSymbol :
CDH2
gene family :
Cadherin
Reactivity :
Human
Usage :
IF, IHC-Fr, IHC-P, IP, WB (1:100 - 1:1000)
ShortWebDescription :
N Cadherin antibody LS-C187536 is an unconjugated mouse monoclonal antibody to human N Cadherin (CDH2) (Cytoplasmic Domain). Validated for IF, IHC, IP and WB.
Synonyms :
CDH2, CDw325, CDHN, Cadherin-2, CD325, CD325 antigen, N Cadherin, N-cadherin, NCAD, Neural cadherin, N-cadherin 1, Neural-cadherin
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.