This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CD276 / B7-H3 Antibody (aa1-242, clone MJ8, RPE) LS-C187524
catalog :
LS-C187524
clonality :
monoclonal
host :
rat
conjugate :
RPE
clone name :
MJ8

The same clone is also sold as:
reactivity :
human, mouse
application :
flow cytometry
product information
AntibodyID :
195427
AntibodyName :
LS-C187524
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
CD276 / B7-H3 Antibody (aa1-242, clone MJ8, RPE) LS-C187524
Specificity :
Recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma, see for details.
ClonalityDesc :
Monoclonal
CloneName :
MJ8
AntibodyModification :
RPE
AntigenModification :
aa1-242
PresentationDesc :
PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA
ImmunogenType :
Fusion protein
ImmunogenDesc :
Mouse IgG2a Fc-CD276 (aa 1-242).
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.
ResuspensionLiquidDesc :
Reconstitute with distilled water.
IsotypeName :
IgG2b
Gene :
CD276 / B7-H3
StandardGeneSymbol :
CD276
Reactivity :
Mouse
Usage :
Flo
ShortWebDescription :
B7-H3 antibody LS-C187524 is an RPE-conjugated rat monoclonal antibody to mouse B7-H3 (CD276) (aa1-242). Validated for Flow.
UsageText :
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Synonyms :
CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, B7H3, B7RP-2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.