This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CD45 / LCA Antibody (clone UM16-6) LS-C187495
catalog :
LS-C187495
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
UM16-6

The same clone is also sold as:
reactivity :
human, chicken
application :
immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
product information
AntibodyID :
195398
AntibodyName :
LS-C187495
TargetSpecies :
Chicken
Host Species :
Mouse
Product Name :
CD45 / LCA Antibody (clone UM16-6) LS-C187495
Specificity :
Clone UM16-6 recognizes chicken CD45 (leucocyte common antigen), a heavily-glycosylated transmembrane protein tyrosine phosphatase (PTPase) expressed by all nucleated cells of hematopoietic origin. Variation in the expression of a particular CD45 isoform is regulated during the hematopoietic development of the different cell lineages. CD45 is essential for antigen-induced signal transduction through the antigen receptor and as with other PTPase family members, acts in balance with protein tyrosine kinases, causing the dephosphorylation of negative regulatory tyrosine sites. Studies have indicated that dephosphorylation by CD45 is required for the activation of the src-family kinases p56lck and p59fyn. Investigations into the properties of CD45 in chicken models are limited, but there is evidence of the existence of an additional cysteine residue near the transmembrane region. The overall domain structure between mammalian and chicken CD45 appears to be conserved, but the sequence homology between the extracellular regions is very low.
ClonalityDesc :
Monoclonal
CloneName :
UM16-6
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenDesc :
COS cells transfected with CD45 gene.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
CD45 / LCA
StandardGeneSymbol :
PTPRC
gene family :
Protein Phosphatase
Subfamily :
R1/R6
Reactivity :
Chicken
Usage :
Flo, IHC-Fr, IP
ShortWebDescription :
LCA antibody LS-C187495 is an unconjugated mouse monoclonal antibody to chicken LCA (CD45). Validated for Flow, IHC and IP.
Synonyms :
PTPRC, B220, CD45R, CD45, gp180, Leukocyte common antigen, L-CA, Leucocyte common antigen, LY5, T200, T200 glycoprotein, T200 leukocyte common antigen, CD45 antigen, LCA
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.