product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 3B11/11) LS-C187491
catalog :
LS-C187491
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3B11/11
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Liu Y, Li R, Qiao S, Chen X, Deng R, Zhang G. Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome virus infection. Vet Res. 2020;51:18 pubmed publisher
product information
AntibodyID :
195394
AntibodyName :
LS-C187491
TargetSpecies :
Pig
Host Species :
Mouse
Product Name :
SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 3B11/11) LS-C187491
Specificity :
Porcine CD169, also known as sialoadhesin or Siglec-1, a member of the sialic acid binding immunoglobulin-like lectin (Siglec) family. CD169 was originally identified in mice and identified as the sialic acid dependent Sheep erythrocyte receptor. CD169 has subsequently been identified in rat, human and pig. Was originally raised as part of a panel of anti porcine macrophage monoclonal antibodies raised against isolated porcine alveolar macrophages. Immunohistochemical analysis indicated restriction to macrophage populations mainly in the spleen, lymph nodes, liver and Peyer's patches. Originally described as a non phagocytic intercellular adhesion receptor, work on porcine CD169 indicated that it may play a role as a viral adhesion receptor and as a targeted receptor for the delivery of toxins and antigens. Detects a band of approximately 190 kD in alveolar macrophage extracts under non-reducing conditions.
ClonalityDesc :
Monoclonal
CloneName :
3B11/11
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Cells
ImmunogenDesc :
Porcine alveolar macrophages.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
SIGLEC1 / CD169 / Sialoadhesin
StandardGeneSymbol :
SIGLEC1
gene family :
Immunoglobulin
Reactivity :
Pig
Usage :
Flo, IHC, IHC-Fr, IP, WB
ShortWebDescription :
Sialoadhesin antibody LS-C187491 is an unconjugated mouse monoclonal antibody to pig Sialoadhesin (SIGLEC1 / CD169). Validated for Flow, IHC, IP and WB. Cited in 1 publication.
Synonyms :
SIGLEC1, CD169, CD169 antigen, SIGLEC-1, Sialoadhesin, SN, DJ1009E24.1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.