This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
NEFH / NF-H Antibody LS-C187452
catalog :
LS-C187452
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, bovine
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
195355
AntibodyName :
LS-C187452
TargetSpecies :
Bovine
Host Species :
Rabbit
Product Name :
NEFH / NF-H Antibody LS-C187452
Specificity :
Recognizes bovine intermediate 200 kD Neurofilament H (NFH), a 1026 amino acid ~200 kD protein involved in the maintenance of neuronal integrity. Neurofilaments are a major component of the cellular cytoskeleton, acting as the most abundant support for the axon cytoplasm. They exist as three neurofilament proteins: 68/70 kD (NFL) 160 kD (NFM) and 200 kD (NFH), which are expressed in both the central and peripheral nervous systems. Although typically expressed by neurons, neurofilaments are also expressed by neuroblastomas, neuromas, gangliogliomas, ganglioneuromas, and ganglioneuroblastomas, as well as paragangliomas, carcinoids, skin neuroendocrine carcinomas, and oat cell carcinomas of the lung. Defects in NFH are responsible for susceptibility to the neurodegenerative disorder amyotrophic lateral sclerosis (ALS) which affects upper and lower motor neurons, and results in fatal paralysis.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
TRIS-GBS, NaCl, 0.05% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
GST-tagged bovine NFH recombinant protein.
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
NEFH / NF-H
StandardGeneSymbol :
NEFH
Reactivity :
Bovine
Usage :
IHC-P (1 µg/ml), WB (0.1 µg/ml)
ShortWebDescription :
NF-H antibody LS-C187452 is an unconjugated rabbit polyclonal antibody to bovine NF-H (NEFH). Validated for IHC and WB.
Synonyms :
NEFH, 200 kDa neurofilament protein, KIAA0845, NFH, NF-H
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.