GRN / Granulin Antibody (aa248-259) LS-C154960 | LifeSpan Biosciences LS-C154960 product information

product summary

company name :

LifeSpan Biosciences

product type :

antibody

product name :

GRN / Granulin Antibody (aa248-259) LS-C154960

catalog :

LS-C154960

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

LifeSpan Biosciences product webpage

citations: 1

Reference
Holler C, Taylor G, Deng Q, Kukar T. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. Eneuro. 2017;4: pubmed publisher

image

image 1 :

GRN antibody (1 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

product information

AntibodyID :

161728

AntibodyName :

LS-C154960

TargetSpecies :

Human

Host Species :

Goat

Product Name :

GRN / Granulin Antibody (aa248-259) LS-C154960

Specificity :

Human GRN / Granulin. This antibody is expected to recognize the C-Terminal part of Granulin-3.

ClonalityDesc :

Polyclonal

AntibodyModification :

Unconjugated

AntigenModification :

aa248-259

PresentationDesc :

TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA

ImmunogenDesc :

Peptide with sequence PQDTVCDLIQSK, from the internal of the protein sequence according to NP_002078.1.

PurificationDesc :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

RecommendedStorageDesc :

Aliquot and store at -20°C. Avoid freeze-thaw cycles.

Gene :

GRN / Granulin

BlockingPeptide :

LS-E27830

StandardGeneSymbol :

GRN

gene family :

Hormone

Reactivity :

Mouse, Rat, Hamster, Human, Monkey

Usage :

Peptide-ELISA (1:8000), WB (1 - 3 µg/ml)

ShortWebDescription :

Granulin antibody LS-C154960 is an unconjugated goat polyclonal antibody to Granulin (GRN) (aa248-259) from human. It is reactive with human, mouse, rat and other species. Validated for Peptide-ELISA and WB. Cited in 1 publication.

UsageText :

Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Approx 75kD band observed in lysates of cell lines A431, A549 and HeLa (calculated MW of 63.5kD according to NP_002078.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (He and Bateman, Cancer Res. 1999 Jul 1;59(13):3222-9. PMID: 10397269). Recommended concentration: 1-3 ug/ml.

Synonyms :

GRN, Acrogranin, CLN11, Epithelin precursor, GEP, gp88, Granulin, Granulin-epithelin, Granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin

SalesRegion :

Worldwide

more info or order :

LifeSpan Biosciences product webpage

company information

LifeSpan Biosciences

2401 Fourth Avenue, Suite 900
Seattle, WA 98121

CustomerSupport@lsbio.com

https://www.lsbio.com

1-206-464-1554

headquarters: USA

Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.