This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
ABCC6 / MRP6 Antibody (clone M6II-31, Concentrated) LS-C134868
catalog :
LS-C134868
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
M6II-31

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
138549
AntibodyName :
LS-C134868
TargetSpecies :
Human
Host Species :
Rat
Product Name :
ABCC6 / MRP6 Antibody (clone M6II-31, Concentrated) LS-C134868
Specificity :
M6II-31 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-31 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-7 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products.
ClonalityDesc :
Monoclonal
CloneName :
M6II-31
AntibodyModification :
Concentrated Unconjugated
PresentationDesc :
Tissue Culture Supernatant, 0.1% Sodium Azide, 0.7% BSA, Serum-free
ImmunogenType :
Recombinant protein
PurificationDesc :
Tissue culture supernatant
RecommendedStorageDesc :
Store at 2-8°C.
IsotypeName :
IgG2a
Gene :
ABCC6 / MRP6
StandardGeneSymbol :
ABCC6
gene family :
Transporter
Subfamily :
ATP-binding cassette - ABCC/MRP
Reactivity :
Human
Usage :
Flo, IHC, IHC-Fr, IHC-P, WB
ShortWebDescription :
MRP6 antibody LS-C134868 is an unconjugated rat monoclonal antibody to human MRP6 (ABCC6). Validated for Flow, IHC and WB.
UsageText :
M6II-31 can be used to detect human MRP6 in cells and tissues. Immunocytochemistry: use 1:20-50 dilution on acetone fixed cytospin preparations. For immunohistochemistry: M6II-31 (use 1:20-50) on acetone fixed frozen sections can be followed by incubation with rabbit anti-rat IgG (1:25, Dako) and an APAAP complex (1:50, Dako). M6II-31 can be used on formaldehyde-fixed paraffin-embedded human tissues, after pretreatment with 0.01 M citric acid (pH 6.0) in distilled water at 100 C for 10 minutes. After incubation of M6II-31 (use 1:20) and washing, slides can be incubated with biotinylated rabbit anti-rat IgG (1:100, Jackson, West Grove) and streptavidin conjugated to horseradish peroxidase (1:500, Zymed, San Francisco, CA). Flow cytometry: optimal conditions still to be defined. Western blotting: use 1:20-50 dilution and anti-rat-HRP.
Synonyms :
ABCC6, ABC34, EST349056, MLP1, MOAT-E, MRP6, MOATE, URG7, PXE1, ARA, GACI2, Pseudoxanthoma elasticum, PXE
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.