This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TLR4 Antibody (clone HTA125, Concentrated) LS-C134837
catalog :
LS-C134837
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HTA125

The same clone is also sold as:
reactivity :
human
application :
immunoprecipitation, flow cytometry
product information
AntibodyID :
138518
AntibodyName :
LS-C134837
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TLR4 Antibody (clone HTA125, Concentrated) LS-C134837
Specificity :
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The HTA125 monoclonal antibody reacts preferentially, especially in flow cytometry, with human TLR4 that is associated with MD-2. HTA125 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to precipitate TLR4 (100 kD).
ClonalityDesc :
Monoclonal
CloneName :
HTA125
AntibodyModification :
Concentrated Unconjugated
PresentationDesc :
PBS, 0.02% Sodium Azide, 0.1% BSA
ImmunogenType :
Recombinant protein
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 2-8°C.
IsotypeName :
IgG2a
Gene :
TLR4
StandardGeneSymbol :
TLR4
gene family :
Toll-like Receptor
Reactivity :
Human
Usage :
Flo, IP
ShortWebDescription :
TLR4 antibody LS-C134837 is an unconjugated mouse monoclonal antibody to human TLR4. Validated for Flow and IP.
UsageText :
The antibody can be used for flow cytometry, immuno precipitation and immunohistology on frozen sections. Furthermore the antibody can be used as antagonist for TLR4, it blocks LPS-induced cytokine production.
Synonyms :
TLR4, CD284, CD284 antigen, Homolog of Drosophila toll, TLR-4, TOLL, ARMD10, Toll-like receptor 4, HToll
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.