This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
GZMB / Granzyme B Antibody (clone GRB-7) LS-C121911
catalog :
LS-C121911
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GrB-7

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
125369
AntibodyName :
LS-C121911
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
GZMB / Granzyme B Antibody (clone GRB-7) LS-C121911
Specificity :
Recognizes the 33kD human serine protease granzyme B. Does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the target cell.
ClonalityDesc :
Monoclonal
CloneName :
GRB-7
AntibodyModification :
Unconjugated
PresentationDesc :
0.02% Sodium Azide, 0.1% BSA
ImmunogenType :
Purified protein
ImmunogenDesc :
Human granzyme B.
PurificationDesc :
Tissue culture supernatant
RecommendedStorageDesc :
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG2a
Gene :
GZMB / Granzyme B
StandardGeneSymbol :
GZMB
gene family :
Protease
Subfamily :
Serine S1
Reactivity :
Human
Usage :
IHC, IHC-Fr, IHC-P, WB (1:20)
ShortWebDescription :
Granzyme B antibody LS-C121911 is an unconjugated mouse monoclonal antibody to human Granzyme B (GZMB). Validated for IHC and WB.
UsageText :
Suitable for use in Western Blot and Immunohistochemistry: 1:20 Stains granzyme B expressing lymphocytes in sections of sublimate formaldehyde as well as formalin fixed paraffin embedded tissues. Does not react with other cell types. Can not be used on frozen sections. Pretreatment with 0.1 M sodium citrate, for 10 min at 100°C in a microwave oven is advised.
Synonyms :
GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.