This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
ER Alpha / Estrogen Receptor Antibody (clone 6F11, Supernatant) LS-C11577
catalog :
LS-C11577
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6F11

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
12318
AntibodyName :
LS-C11577
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
ER Alpha / Estrogen Receptor Antibody (clone 6F11, Supernatant) LS-C11577
Specificity :
Recognizes the human estrogen receptor alpha chain (ERalpha), also known as the estradiol receptor or nuclear receptor subfamily 3 group A member 1. ERalpha is a ~65kD steroid hormone receptor containing an N-terminal. ligand independent transactivation domain, a DNA binding domain and a C-terminal ligand binding domain which overlaps with an. ERalpha binds to DNA as a homodimer and can also form heterodimers with Estrogen receptor beta The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formalin fixed, paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays, to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patients prognosis and the effectiveness of hormonal therapy. Has been used successfully for identification of ERalpha on breast cancer cell lysates using Western blotting and for the immunohistochemical detection of ERalpha in breast cancer tissues.
ClonalityDesc :
Monoclonal
CloneName :
6F11
AntibodyModification :
Supernatant Unconjugated
PresentationDesc :
0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human estrogen receptor (alpha form).
PurificationDesc :
Tissue culture supernatant
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
ResuspensionLiquidDesc :
1 ml Distilled Water.
IsotypeName :
IgG1
Gene :
ER Alpha / Estrogen Receptor
StandardGeneSymbol :
ESR1
gene family :
NHR
Subfamily :
NR3 Steroid receptor
Reactivity :
Human
Usage :
IHC-Fr (1:40 - 1:60), IHC-P (1:40 - 1:80)
ShortWebDescription :
Estrogen Receptor antibody LS-C11577 is an unconjugated mouse monoclonal antibody to human Estrogen Receptor (ER Alpha). Validated for IHC.
UsageText :
Immunohistology: Zamboni's fixative recommended for best results. #This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
Synonyms :
ESR1, Era, ERalpha, Estrogen receptor, ER-alpha, Estrogen receptor 1, NR3A1, ER, ESR, ESRA, Estrogen receptor alpha
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.