product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
TP53 / p53 Antibody (aa20-25, clone DO-1) LS-C11553
catalog :
LS-C11553
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DO-1
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; human
Shao L, Zhu B, Xing C, Yang X, Young W, Cao J. Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. Mol Med Rep. 2016;13:2661-70 pubmed publisher
product information
AntibodyID :
12294
AntibodyName :
LS-C11553
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TP53 / p53 Antibody (aa20-25, clone DO-1) LS-C11553
Specificity :
Recognizes the human p53 tumor suppressor protein, also known as cellular tumor antigen p53 or NY-CO-13. Clone DO-1 binds to both wild type and mutant forms of the p53 protein found in various malignancies. p53 is important in multicellular organisms, where it regulates cell cycle progression to allow DNA repair or apoptosis in the case of irreparably damaged cells and thus functions as a tumor suppressor that is involved in preventing cancer. Mutations in the p53 gene are found in about half the cases of human cancerrecognizes an epitope at the N-terminal end of p53 between amino acids 20-25, common to isoforms 1-3 of p53.
ClonalityDesc :
Monoclonal
CloneName :
DO-1
AntibodyModification :
Unconjugated
AntigenModification :
aa20-25
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human p53 (AA 20-25)
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
TP53 / p53
StandardGeneSymbol :
TP53
gene family :
P53
Reactivity :
Human
NonReactiveSpecies :
Mouse, Rat
Usage :
ELISA, IHC, IHC-Fr, IHC-P (1:25), IP, WB (1:1000)
ShortWebDescription :
P53 antibody LS-C11553 is an unconjugated mouse monoclonal antibody to human p53 (TP53) (aa20-25). Validated for ELISA, IHC, IP and WB. Cited in 1 publication.
UsageText :
Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. We recommend the use of 0.01 M citrate buffer for this purpose.
Synonyms :
TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.