This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TIMP1 Antibody LS-C11473
catalog :
LS-C11473
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section
product information
AntibodyID :
12214
AntibodyName :
LS-C11473
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
TIMP1 Antibody LS-C11473
Specificity :
Recognizes human Tissue inhibitor of metalloproteinases 1, also known as TIMP-1, Metalloproteinase inhibitor 1, Erythroid-potentiating activity or Fibroblast collagenase inhibitor. TIMP-1 is a 207 amino acid, ~23 kD secreted glycoprotein containing a 23 amino acid signaling peptide and a single domain. TIMP-1 is a metalloproteinase inhibitor that functions by formation of complexes with target metalloproteinases, binding to their catalytic cofactor leading to irreversible inactivation of the target metalloproteinase. TIMP-1 also functions as a growth factor and activates signalling cascades via CD63 and CD29. In humans TIMP-1 also functions to promote growth and differentiation of erythroid progenitors. Recognizes both native and denatured TIMP-1, as well as TIMP-1 in and out of enzyme/inhibitor complex. Is not known to be neutralizing. TIMP-1 is expressed by a wide range of cells including microvascular endothelial cells, smooth muscle cells, mesangial cells and some fibroblasts. Has been used successfully for the localization of TIMP-1 in a rabbit model of hypertrophic scarring by immunohistochemistry on formalin fixed, paraffin embedded sections.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.02% Sodium Azide
ImmunogenDesc :
Human tissue inhibitor of metalloproteinase 1 (TIMP-1).
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
TIMP1
StandardGeneSymbol :
TIMP1
Reactivity :
Human
Usage :
ELISA (2.5 - 10 µg/ml), IHC, IHC-P (1 - 5 µg/ml), WB (5 - 10 µg/ml)
ShortWebDescription :
TIMP1 antibody LS-C11473 is an unconjugated rabbit polyclonal antibody to human TIMP1. Validated for ELISA, IHC and WB.
Synonyms :
TIMP1, CLGI, EPA, HCI, Metalloproteinase inhibitor 1, TIMP-1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.