product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
EDN1 / Endothelin 1 Antibody (C-Terminus, clone IC4) LS-C11319
catalog :
LS-C11319
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
IC4
reactivity :
primate, human, rhesus macaque
application :
immunohistochemistry, immunohistochemistry - frozen section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; primate
  • immunohistochemistry - frozen section; rhesus macaque
Keator C, Mah K, Ohm L, Slayden O. Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium. Hum Reprod. 2011;26:1715-28 pubmed publisher
product information
AntibodyID :
12060
AntibodyName :
LS-C11319
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
EDN1 / Endothelin 1 Antibody (C-Terminus, clone IC4) LS-C11319
Specificity :
Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10% reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.
ClonalityDesc :
Monoclonal
CloneName :
IC4
AntibodyModification :
Unconjugated
AntigenModification :
C-Terminus
PresentationDesc :
PBS, 0.1% Sodium Azide
ImmunogenDesc :
C-Terminus fragment of human endothelin 1.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
EDN1 / Endothelin 1
StandardGeneSymbol :
EDN1
gene family :
Hormone
Reactivity :
Human
Usage :
IHC, IHC-Fr, IRMA
ShortWebDescription :
Endothelin 1 antibody LS-C11319 is an unconjugated mouse monoclonal antibody to human Endothelin 1 (EDN1) (C-Terminus). Validated for IHC and IRMA. Cited in 1 publication.
Synonyms :
EDN1, Endothelin 1, Endothelin-1, ET1, Preproendothelin-1, PPET1, HDLCQ7
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.