product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ ADAM17 / TACE Antibody (aa807-823) LS-B619
catalog :
LS-B619
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse
Johansson E, Grassi E, Pantazopoulou V, Tong B, Lindgren D, Berg T, et al. CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells. Cell Rep. 2017;20:1641-1653 pubmed publisher
Lattenist L, Ochodnický P, Ahdi M, Claessen N, Leemans J, Satchell S, et al. Renal endothelial protein C receptor expression and shedding during diabetic nephropathy. J Thromb Haemost. 2016;14:1171-82 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B619 image 1
Anti-ADAM17 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
product information
AntibodyID :
32847
AntibodyName :
LS-B619
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
IHC-plus™ ADAM17 / TACE Antibody (aa807-823) LS-B619
Specificity :
Amino acids 807 to 823 of human TACE
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa807-823
PresentationDesc :
PBS, 0.02% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide from human ADAM17.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Gene :
ADAM17 / TACE
StandardGeneSymbol :
ADAM17
gene family :
Protease
Subfamily :
Metallopeptidase M12B
Reactivity :
Mouse, Rat, Human
Usage :
IHC, IHC-P (20 µg/ml), WB
ShortWebDescription :
TACE antibody LS-B619 is an unconjugated rabbit polyclonal antibody to TACE (ADAM17) (aa807-823) from human. It is reactive with human, mouse and rat. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
UsageText :
Immunohistochemistry: LS-B619 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B619 was determined to be 20 ug/ml.
Synonyms :
ADAM17, CD156B, CD156b antigen, CSVP, ADAM 17, NISBD, TNF-alpha converting enzyme, TNF-alpha convertase, TNF-alpha-converting enzyme, Snake venom-like protease, TACE
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.