This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ TRF1 / TERF1 Antibody (clone BED5) LS-B5949
catalog :
LS-B5949
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BED5

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
143622
AntibodyName :
LS-B5949
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
IHC-plus™ TRF1 / TERF1 Antibody (clone BED5) LS-B5949
Specificity :
Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.
ClonalityDesc :
Monoclonal
CloneName :
BED5
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant TRF1
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
TRF1 / TERF1
StandardGeneSymbol :
TERF1
Reactivity :
Human
Usage :
ELISA, IHC, IHC-Fr, IHC-P (10 µg/ml)
ShortWebDescription :
TERF1 antibody LS-B5949 is an unconjugated mouse monoclonal antibody to human TERF1 (TRF1). Validated for ELISA and IHC. Tested on 20 paraffin-embedded human tissues.
UsageText :
Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose Histology Positive Control Tissue: Human tonsil.
Synonyms :
TERF1, HTRF1-AS, NIMA-interacting protein 2, PIN2, Telomeric protein Pin2/TRF1, TRBF1, TTAGGG repeat-binding factor 1, T-TRF1, TRF, TRF1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.