product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ PR / Progesterone Receptor Antibody LS-B5236
catalog :
LS-B5236
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 5
Reference
Ezoe K, Murata N, Yabuuchi A, Kobayashi T, Kato K. Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model. Sci Rep. 2019;9:12519 pubmed publisher
Janardhan K, Jensen H, Clayton N, Herbert R. Immunohistochemistry in Investigative and Toxicologic Pathology. Toxicol Pathol. 2018;46:488-510 pubmed publisher
Suen A, Jefferson W, Williams C, Wood C. Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice. Toxicol Pathol. 2018;46:574-596 pubmed publisher
Jackson Humbles D, Seely J, Herbert R, Malarkey D, McIntyre B, Foster P, et al. Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies. Toxicol Pathol. 2018;46:421-430 pubmed publisher
Ezoe K, Daikoku T, Yabuuchi A, Murata N, Kawano H, Abe T, et al. Ovarian stimulation using human chorionic gonadotrophin impairs blastocyst implantation and decidualization by altering ovarian hormone levels and downstream signaling in mice. Mol Hum Reprod. 2014;20:1101-16 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B5236 image 1
Anti-PGR / Progesterone Receptor antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
product information
AntibodyID :
139785
AntibodyName :
LS-B5236
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
IHC-plus™ PR / Progesterone Receptor Antibody LS-B5236
Specificity :
Equally recognizes two proteins: 116kD (triplet) and 81kD (singlet) which are identified as the hormone-binding high (B) and low (A) MW forms of human progesterone receptor. This antibody recognizes an epitope in the N-terminal half of human PgR. Species cross-reactivity: baboon, monkey, mouse and rat. Does not cross-react with guinea pig.
ClonalityDesc :
Monoclonal
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, pH 7.4, 0.09% Sodium Azide, 0.2% BSA
ImmunogenDesc :
Progesterone Receptor from a human endometrial carcinoma (EnCa 101) grown in athymic mice.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
May be stored at 4°C for short-term only. Aliquot to avoid freeze-thaw cycles. Store at -20°C. Aliquots are stable for up to 1 year.
IsotypeName :
IgG1,k
Gene :
PR / Progesterone Receptor
StandardGeneSymbol :
PGR
gene family :
NHR
Subfamily :
NR3 Steroid receptor
Reactivity :
Mouse, Rat, Human, Monkey
Usage :
IF, IHC, IHC-P (1:50), IP, WB (1 - 2 µg/ml)
ShortWebDescription :
Progesterone Receptor antibody LS-B5236 is an unconjugated mouse monoclonal antibody to Progesterone Receptor (PR) from human. It is reactive with human, mouse, rat and other species. Validated for IF, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues. Cited in 5 publications.
UsageText :
Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, and Sedimentation in sucrose gradients. Immunoprecipitation (NATIVE ONLY): 2 ug/mg protein lysate Using Protein G. Western Blot: 1-2 ug/ml for 2 hrs at RT. Positive control: T47D cells or breast carcinoma.
Synonyms :
PGR, NR3C3, PR, Progesterone receptor
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.